Pathology Sample Question

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Sample Question on Pathology

1. FIGLU excretion test is used for assessment of deficiency of
(1) Vitamin B12
(2) Pyridoxine
(3) Folic Acid
(4) Niacin

2. In Down Syndrome there is non-dysjunction of chromosome :
(1) Chromosome 13
(2) Chromosome 15
(3) Chromosome 18
(4) Chromosome 21

3. Which of the following changes best describe the pathophysiology involved in the production of pulmonary oedema in patients with congestive heart failure ?
(1) Wide spread endothelial damage
(2) Decreased plasma oncotic pressure
(3) Increased hydrostatic pressure
(4) Acute lymphatic obstruction

4. All are reversible injury of cell, except :
(1) Vacuole
(2) Karyorrhexis
(3) Fat accumulation
(4) Cell wall swelling

5. Which cells can lyse tumour cells or virus injected cells without prior sensitization ?
(1) B Cells
(2) T Cells
(3) NK Cells
(4) Macrophages

6. Pro-apoptotic proteins are :
(1) bel 2—bel x L
(2) bel 2-Mel-1
(3) Bax and Bak
(4) Ced9

7. In cell death myelin figures are derived from
(1) Plasma Membrane
(2) Cytoplasm
(3) Nucleus
(4) Mitochondria

8. Wear and tear pigment in the body refers to
(1) Melanin
(2) Lipochrome
(3) Haemosiderin
(4) Anthracotic pigment

9. All are features of carcinoma, except :
(1) Anaplasia
(2) Metaplasia
(3) Dysplasia
(4) Autonomous

10. Not a premalignant condition :
(1) Ulcerative colitis
(2) Achalasia cardiac
(3) Xeroderma pigmentosa
(4) Barrettes oesophagus

11. Which of the following is oncogenic RNA virus ?
(1) HPV
(2) HHV-8
(3) HTLV-1
(4) EBV

12. Which of the complement components act as a chemo-attractant ?
(1) C4b
(2) C4a
(3) C3b
(4) C55a

13. Which of the following is autosomal recessive disorder ?
(1) Marfan Syndrome
(2) Hereditary Spherocytosis
(3) Homocystinurea
(4) Myotonic dystrophy

14. HLA-B 27 is associated with
(1) Rheumatoid arthritis
(2) Osteo arthritis
(3) Ankylosing Spondylitis
(4) Suppurative arthritis

15. The most common cause of acute bacterial meningitis in neonates is
(1) Listeria monocytogenes
(2) H. influenza
(3) Escherichia coli
(4) Streptococcus pneumonia

16. All are antigen presenting cell, except :
(1) Langerhan’s cells
(2) Dendritic cells
(3) T-Cells
(4) B-Cells

17. Cytokeratin is a tumour marker for
(1) Melanoma
(2) Carcinoma
(3) Sarcoma
(4) Lymphoma

18. Soft chancre is caused by
(1) Syphilis
(2) Tuberculosis
(3) Chancroid
(4) L. donovaoni

19. All are cellular adaptation, except –
(1) Hypertrophy
(2) Hyperplasia
(3) Necrosis
(4) Metaplasia

20. Which Thyroid carcinoma has amyloid deposition ?
(1) Anaplastic
(2) Papillary
(3) Follicular
(4) Medullary

21. Red infarct is seen in
(1) Liver
(2) Brain
(3) Kidney
(4) Lung

22. CD marker for cytotoxic T cells :
(1) CD4
(2) CD8
(3) CD21
(4) CD45

23. Fatty liver is due to accumulation of
(1) Lipoprotein
(2) LDL
(3) Triglyceride
(4) VLDL

24. A simple bacterial test for mutagenic carcinogens is
(1) Ames test
(2) Redox test
(3) Bacteriophage
(4) Gene Splicing

25. Acanthosis means
(1) Loss of intracellular connection
(2) Abnormal premature keratinization
(3) Diffuse epidermal hyperplasia
(4) Thickening of stratum corneum

26. Hemartoma is
(1) Malignant tumour
(2) Benign tumour
(3) Haemorrhage in vessel
(4) Development malformation
27. Liquefactive necrosis is seen in
(1) Heart
(2) Brain
(3) Lung
(4) Spleen

28. Squamous Cell Carcinoma spread commonly via
(1) Implantation
(2) Haematogenous Spread
(3) Lymphatic Spread
(4) Transcoelomic Spread

29. Heart failure cells are
(1) Lipofuscin granules in cardiac cells
(2) Pigmented alveolar macrophages
(3) Pigmented pancreatic acinar cells
(4) Pigmented cells in liver

30. Excessive fibrosis tumours is called
(1) Anaplasia
(2) Metaplasia
(3) Dysplasia
(4) Desmoplasia

31. What is hyperplasia ?
(1) Decrease in cell size
(2) Increase in cell size
(3) Increase in cell number
(4) Decrease in cell number

32. Which of the following cellular adaptation may be irreversible ?
(1) Atrophy
(2) Metaplasia
(3) Hyperplasia
(4) Hypertrophy

33. Calcification in necrotic tissue is called :
(1) Metastatic Calcification
(2) Dystrophic Calcification
(3) Calcinosis
(4) Tumoral Calcinosis

34. Epithelioid cell is a modified :
(1) Lymphocyte
(2) Eosinophil
(3) Mast Cell
(4) Macrophage

35. Fat necrosis occurs in
(1) Omentum
(2) Heart
(3) Kidney
(4) Brain

36. Diabetic foot is associated with following type of gangrene :
(1) Dry gangrene
(2) Wet gangrene
(3) Gas gangrene
(4) Fournier’s gangrene

37. Russell bodies are seen in
(1) Lymphocytes
(2) Neutrophil
(3) Macrophage
(4) Plasma cell

38. Rubor in inflammation is due to
(1) Dilation of arterioles
(2) Increased vascular permeability
(3) Increased viscosity of blood
(4) Edema

39. Opsonins are
(1) C3a
(2) IgM
(3) IgE
(4) Sclectins

40. Grade of tumour denotes
(1) Degree of differentiation
(2) Stage of disease
(3) Vascular invasion
(4) Degree of anaplasia

41. The most common source of embolism :
(1) Deep Vein Thrombosis (DVT)
(2) Trauma
(3) Infection
(4) Surgery

42. Hereditary angioedema is due to deficiency of
(1) Angiotensin
(2) Angiotensin converting enzyme
(3) C1 inhibitor
(4) Histamin

43. Autoimmunity is caused
(1) Inappropriate selection of MHC proteins
(2) Negative selection of T cells in thymus
(3) Expression of cryptic antigens
(4) Pressure of forbidden clones

44. Which cell type lacks HLA antigen ?
(1) Monocyte
(2) Thrombocyte
(3) Neutrophil
(4) Red blood cell

45. Immune system in the body is activated by
(1) Cell adhesion molecules
(2) Cytokines
(3) G-protein receptors
(4) Ion Channels