Pathology Questions and Answers

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Pathology Questions and Answers

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Questions and Answers on Pathology

1. The Fenton reaction leads to free radical generation when :
1) Radiant energy is absorbed by water
2) Hydrogen Peroxide is formed by Myeloperoxidase
3) Ferrous ion are converted to Ferric ions
4) Nitric Oxide is converted to peroxynitrate anion

2. Russell bodies are seen in:
1) Lymphocytes
2) Neutrophils
3) Macrophages
4) Plasma cell

3. Neutrophil secretes:
1) Lysosomal enzyme
2) Superoxide dismutase
3) Catalase
4) Cathepsin

4. Crooke’s hyaline body is presented in
1) Yellow fever
2) Basophil cells of the pituitary glans in cushing syndrome
3) Parkinsonism
4) Huntington’s disease

5. Which of the following statement about Telomerase is true
1) Has RNA polymerase activity
2) Causes carcinogenesis
3) Present in somatic cells
4) Absent in germ cells

6. Pyroptosis has all the features except
1) occurs in cells infected by microbes
2) Activation of capase-1
3) Generates biologically active IL-1
4) Triggered by viral proteins of RNA and DNA virus

7. Oxygen dependent killing is done through :
1) NADPH oxidase
2) Superoxide dismutase
3) Catalase
4) Glutathione peroxidase

8. Which are of the following is most important diapedesis
1) PECAM-1
2) Selectin
3) Integrin
4) Mucin like glycoprotein

9. Which of the following is not an inflammatory mediator
1) Tumour Necrosis factor
2) Myeloperoxidase
3) Interferons
4) Interleukin

10. Lewis triple response is caused due to:
1) Histamine
2) Axon reflex
3) injury to endothelium
4) Increased permeability

11. Which complement fragments are called anaphylatoxins?
1) C3a and C3b
2) C3b and C5b
3) C5a and C3b
4) C3a and C5a

12. Cryoprecipitate is rich in which of the following clotting factors:
1) Factor II
2) Factor V
3) Factor VII
4) Factor VIII

13. Opsonins are :
1) C3a
2) Ig M
3) Carbohydrate binding proteins
4) Selectins

14. The following type of renal calculi are radiolucent
1) Calcium oxalate
2) Struvite
3) Uric acid
4) Calcium phosphate

15. Prion disease is caused by:
1) Misfolding of proteins
2) Denaturation of Proteins
3) Reduced formation of proteins
4) Excess formation of proteins

16. Who established the concept of chemical substances such as histamine (produced in response to injury) mediate the vascular changes of inflammation:
1) Celsus
2) Rudolf Virchow
3) Sir Thomas Levis
4) Elie Metchnikoff

17. All endothelial cells produce thrmbomodulin except those found in :
1) Hepatic circulation
2) Cuteneous circulation
3) Cerebral Microcirculation
4) Renal circulation

18. Lung abscess secondary to aspiration pneumonia develops more often in:
1) Lower lobe of right lung
2) Lower lobe of left lung
3) Upper lobe of either lung
4) Middle lobe of right lung

19. Congenital hypercoagulability states are all of the following EXCEPT:
1) Protein C deficiency
2) Protein S deficiency
3) Anti-phospholipid antibody syndrome
4) MTHFR gene mutation

20. Arterial Thrombosis is seen in:
1) Anti-phospholipid antibody syndrome
2) Protein S deficiency
3) Protein C deficiency
4) Antithrombin III deficiency

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21. The initiating mechanism in endotoxic shock is
1) Peripheral vasodilation
2) Endothelial injury
3) Increased vascular permeability
4) Reduced cardiac output

22. Characteristic inclusion seen in parkinsonism are
1) Hirano bodies
2) Nerofibrillary tangle
3) Negri bodies
4) Lewy bodies

23. Which of the following disorder has been shown to be genetically transmitted by single autosomal dominant gene
1) Catatonic Schizophrenia
2) Phenylketonuria
3) Creutzfeldt- Jakob’s disease
4) Huntington’s disease

24. Which one is NOT a feature of cystic fibrosis?
1) Autosomal recessive disease
2) Abnormal chloride transport
3) affects intestine only
4) Increased risk of pulmonary infections

25. In prader Willi syndrome , which one of the following is increased?
1) LH
2) FSH
3) TSH
4) Ghrelin

26. Which one of the following type of bronchigenic carcinoma has the worst prognosis
1) Squamous cell carcinoma
2) Small cell carcinoma
3) Large cell carcinoma
4) Adenocarcinoma

27. Which of the following techniques can be used to detect exact localisation of a genetic locus
1) Chromosome painting
2) FISH
3) Comaparative genomic hybridization
4) Western blot

28. Gene for Wilm’s tumour is located on:
1) Chromosome 1
2) Chromosome 10
3) Chromosome 11
4) Chromosome 12

29. What does a Ames test evaluate?
1) Experimental induction
2) Test for mutagenicity
3) Carcinogenasis by ionizing radiation
4) viral carcinogenesis

30. F body is
1) X chromatin
2) Y chromatin
3) Chromosome 11
4) Chromosome 21

31. Rh incompatibility disease of newborn means:
1) Type 1 Hypersensitivity
2) Type 2 Hypersensitivity
3) Type 3 Hypersensitivity
4) Type 4 Hypersensitivity

32. Migratory thrombophlebitis is associated with all of the following malignancies except:
1) Prostate
2) Lung
3) GIT
4) Pancreas

33. Tumour that follows rule of 10 is :
1) Pheochrmocytoma
2) Oncocytoma
3) Lymphoma
4) Renal cell carcinoma

34. Epidermal growth factor receptor 1(EGFR 1) is NOT involved in one of the following cancers:
1) Lung
2) Head & Neck
3) Breast
4) Liver

35. Which of the following mutation is seen in malignant Melanoma?
1) N-myc
2) CDKN2A
3) RET
4) Rb

36. The term pseudomalignant osseous tumour is used for the following condition:
1) Myositis ossificans
2) Osteochondroma
3) Osteoid osteoma
4) Osteoblastoma

37. Which one is not correctly paired
1) SMA- smooth muscle tumour
2) S-100-Skeletal Muscle tumour
3) Factor VIII- vascular tumour
4) LCA – Lymphoid cells

38. Perforins are produced by:
1) Cytotoxic T cells
2) Suppressor T cells
3) Memory helper T cells
4) Plasma cell

39. NK cells express:
1) CD 15, CD 55
2) Cd 16, CD 56
3) Cd 16, CD 57
4) Cd 21, CD 66

40. Which of the following type of hypersensitivity reaction is found in blood transfusion reaction
1) Anaphylatic type
2) Cytotoxic type
3) Type 3 Hypersensitivity
4) Cell mediated hypersensitivity

41. Myasthenia gravis is most commonly associated with which of the following?
1) Thymoma
2) Thymic carcinoma
3) Thymic hyperplasia
4) Lymphoma

42. Anti- topoisomerase is marker of:
1) Systemic sclerosis
2) Classic polyarteritis nodosa
3) Nephrotic syndrome
4) Rheumatoid arthritis

43. “Macropolycytes” in peripheral smear is a feature of:
1) Hereditary spherocytosis
2) Iron deficiency anemia
3) Sickle cell anemia
4) Megaloblastic anemia

44. Mircroangiopathic haemolytic anemia seen in all except:
1) Thrombotic thrombocytopenic purpura
2) Hemolytic uremic syndrome
3) Henoch- Schonlein purpura
4) DIC

45. Paroxysmal nocturnal haemoglobinuria (PNH) due to defect in:
1) CD 59
2) CD 15
3) CD 100
4) CD 20