Endocrinology MCQ
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MCQ on Endocrinology
1. Which of the following is not true about VHL syndrome ?
(1) Autosomal dominant mode of transmission.
(2) Mutation in VHL located on Chr 10q 11.2.
(3) Manifest benign/malignant neoplasm like pheochromocytoma/ paraganglioma / Hemangioblastoma & Retinal angioma
(4) Average age of detection of pheochromocytoma is 20 to 29 years.
2. Which of clinical / laboratory feature does not correlate with adrenal crisis ?
(1) Hypoglycemia
(2) Hypotension / shock
(3) Hyponatremia
(4) Hypothermia
3. Which of the following enzyme catalyzes the rate limiting step in catecholamine synthesis ?
(1) Tyrosine kinase
(2) Catechol-O-Methyl transferase
(3) Dopa-decarboxylase
(4) Mono-amine oxidase
4. Which of the following drug is not used in pre-operative management of hypertension due to pheochromocytoma ?
(1) Prozocin
(2) Labetalol
(3) Losartan
(4) Metyrosine
5. Which of the following drug is safe to induce anesthesia in a patient to be operated for pheochromocytoma ?
(1) Fentanyl
(2) Morphine
(3) Propranolol
(4) Ketamine
6. Which of the following is not included in Carney Triad ?
(1) Gastrointestinal stromal tumor
(2) Retinal Angiomas
(3) Pulmonary Chondroma
(4) Paraganglioma
7. 11 β Hydroxylase deficiency arises because of mutation in :-
(1) 11 β Hydroxylase (CYP 11 B1) gene
(2) Cytochrome P-450 gene
(3) 11 β Hydroxylase (CYP 11 CI) gene
(4) 11 β Hydroxylase (CYP 11 EI) gene
8. All can be cause for monogenic cause of obesity EXCEPT :-
(1) Single minded Homolog 1 (SIMI 1) gene mutation
(2) Prohormone convertase I gene mutation
(3) Adiponectin SX-4 mutation
(4) Src Homology 2B1 (SH2 B1) deficiency
9. All can be secreted from adipocyte EXCEPT :-
(1) Angiotensinogen
(2) Interleukin 12
(3) Interleukin 6
(4) Complement C3
10. Following are characteristics of Brown adipose tissue EXCEPT :-
(1) It contains multilocular fat vacuoles
(2) Large Mitochondria
(3) Intense innervation by sympathetic nerves.
(4) Human BAT cannot be activated by cold exposure.
11. Phentermine an antiobesity drug is a/an :-
(1) Sympathomimetic agent
(2) Parasympathetic agent
(3) Also acts on GLP-I Receptor
(4) Antagonist of serotonin release
12. Leptin is the product of :-
(1) 8bc gene
(2) db gene
(3) ob gene
(4) NP4 gene
13. Activity of 1 α Hydroxylase is inhibited by following except :
(1) Calcium
(2) 1,2, 5 Dihydroxy Vitamin D
(3) FGF-23
(4) PTH
14. Which of the following hormones do not act via GPCR ?
(1) TSH
(2) Vit D receptor
(3) MSH
(4) ACTH
15. Which of the following is/are peptide/protein hormone ?
(1) IGF
(2) ANP
(3) ADH
(4) All of the above
16. Which of the following is not derived from amino acid ?
(1) Calcitonin
(2) Dopamine
(3) Serotonin
(4) Norepinephrine
17. What is the mode of inheritance of familial hypocalciuric hydrocalcemia ?
(1) AR
(2) XLR
(3) AD
(4) XLD
18. Which of the following gene mutation cause Mc Caine Albright syndrome ?
(1) FGFR 1
(2) RET
(3) GNAS 1
(4) NFE
19. Which of the following hormones act through nuclear receptor ?
(1) Aldosterone
(2) Thyroid hormone
(3) Cortisol
(4) All of the above
20. Which of the following is not true about type B insulin resistance ?
(1) Present at age less than 18 years of age.
(2) Often present with autoimmune conditions like Vitiligo, Alopecia & arthritis.
(3) Presence of antibody directed against insulin receptor.
(4) Level of antibody correlates with severity disease.
Practice Set | Quiz |
MCQs | Questions and Answers |
21. “Hook effect” have been extensively reported in following hormone :-
(1) Prolactin
(2) Calcitonin
(3) hCG
(4) All of above
22. Which of the following type of diabetes do not follow Mendelian pattern of inheritance ?
(1) MODY
(2) Type 2 diabetes mellitus
(3) Neonatal diabetes
(4) Congenital Lipodystrophies
23. Which of the following hormones has identical a-subunit of FSH ?
(1) TSH
(2) LH
(3) hCG
(4) All of above
24. Which of the following is the most prevalent endocrinopathy across the world ?
(1) Diabetes insipidus
(2) Thyroid diseases
(3) Adrenal diseases
(4) Diabetes Mellitus
25. The most potent natural ligand for Vit D receptor is :-
(1) 1,25 dihydroxy Vit D
(2) 25 Hydroxy Vit D
(3) 1,24 dihydroxy Vit D
(4) 24, 25 dihydroxy Vit D
26. Which of the following is not a fat soluble Vitamin ?
(1) Vitamin A
(2) Vitamin D
(3) Vitamin C
(4) Vitamin K
27. Paracrine cells secrete their contents :-
(1) Directly into the blood stream
(2) Into extracellular space to act on neighboring cells
(3) Locally to affect their own function
(4) Into the lumen of ductal system
28. Post ganglionic sympathetic neurons secrete which neurotransmitter at sweat glands ?
(1) Acetyl Choline
(2) Dopamine
(3) Nor-Adrenaline
(4) Serotonin
29. Kallman syndrome is due to defective migration of :-
(1) Somatostatin secreting neurons and is associated with Hemianopia.
(2) GnRH secreting neurons and is associated with hemianopia.
(3) Somatostatin secreting neurons and is associated with anosmia.
(4) GnRH secreting neurons and associated with anosmia.
30. Dorsal invagination of Rathke’s pouch gives rise to :-
(1) Anterior and posterior lobes to pituitary
(2) Second pharyngeal arch
(3) Anterior and intermediate lobes of pituitary
(4) Tuber cinerium
31. Median eminence part of pituitary gland is richly supplied by :-
(1) Superior hypophyseal branch of ICA.
(2) Inferior hypophyseal branch of ICA.
(3) Anterior hypophyseal branch of ECA.
(4) Posterior hypophyseal branch of ECA.
32. Which of the following is not a polypeptide hormone ?
(1) PRL
(2) TSH
(3) POMC
(4) GH
33. All are causes of hyper-prolactinaemia EXCEPT :-
(1) Phenothiazine
(2) Methyl dopa
(3) Metoclopromide
(4) Amlodipine
34. Most abundant hormone in adult pituitary gland is :-
(1) GH
(2) Prolactin
(3) Gonadotropins
(4) ACTH
35. Confirmatory test for acromegaly is :-
(1) Insulin induced GH suppression.
(2) Glucose induced GH suppression.
(3) Clonidine induced GH stimulation.
(4) Propranolol induced GH suppression.
36. False about Carney’s complex :-
(1) Cardiac myxomas
(2) Related to chromosome
(3) Autosomal recessive
(4) Pituitary adenoma with spotty skin pigmentation
37. Neuroepithelial cell lining of which ventricle give rise to PVN and SON of :-
(1) Third ventricle
(2) Lateral ventricle
(3) Fourth ventricle
(4) Both (1) & (2)
38. The major inhibitory and stimulatory neurotransmitters in neurohypophyses are respectively :-
(1) Dopamine and serotonin
(2) Serotonin and dopamine
(3) Glutamate and GABA
(4) GABA and Glutamate
39. Vasopressin and oxytocin hormones are :-
(1) Decapeptides
(2) Nonapeptides
(3) Octapeptides
(4) Heptapeptides
40. Vasopressin receptors responsible for stimulating ACTH – secretion from anterior pituitary and for increasing factor VIII and Von Willibrand factor production are :-
(1) V1a and V2
(2) V2 and V1a
(3) V1b and V2
(4) V2 and V1b
41. Oxytocinase (vasopressinase) in pregnant females is produced by :-
(1) Placenta
(2) Endometrium
(3) Maternal pituitary
(4) Fetal pituitary
42. Choose the best lab value for urinary osmolarity and serum osmolarity in a patient with central diabetes insipidus :-
(1) 50 and 300
(2) 500 and 260
(3) 50 and 260
(4) 50 and 100
43. SIADH is associated with the following drug :-
(1) Erythromycin
(2) 5-Fu
(3) Methotrexate
(4) Vincristine
44. Which drug is not used in SIADH ?
(1) Fludrocortisone
(2) Desmopressin
(3) Demeclocycline
(4) Hypertonic saline
45. Which of the following is true for diabetes insipidus ?
(1) Urine osmolality > 300
(2) Plasma osmolality < 280
(3) Water deprivation test
(4) Plasma osmolality, should be > 300 prior to water deprivation