Pathology Mock Test

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Mock Test on Pathology

1. Which one of the following statements is not true about Hepatocellular adenoma:
1) Main risk factor is exposure to estrogen or androgen
2) It can transfors to hepatocellular carcinoma
3) It is always single
4) β-catenin mutation and HNF-1 mutation can be seen in some of the types

2. Which one of the following is not a preferred method for HPV test in cervical smear screening:
1) ELISA
2) Hybrid capture
3) Real time PCR
4) Invader probe chemistry

3. Following is not true about Tensin family of genes:
1) They are regulator of cell migration
2) They have role in regulation of apoptosis
3) They are derived from complements
4) They can act as tumour suppressor gene

4. Which one is a false statement about Barrett’s oesophagus:
1) Replacement of lower oesophageal squamous mucosa by metaplastic glandular mucosa
2) Gastro-oesophageal reflux disease is an initiating factor
3) H. pylori infection of stomach is a risk factor
4) It is more common in overweight males

5. Which one of the following enzymes has role in regulation of extracellular matrix and progression of neoplasm:
1) Hyaluronidase
2) α-1 antitrypsin
3) Endonuclease
4) Matrix metalloproteinases

6. In which respect Gastro-intestinal Stromal tumour (GIST) is similar to Chronic Myeloid Leukemia (CML):
1) CD-117 positivity
2) Origin from Interstitial cells of Cajal
3) Responsiveness to Imatinib as Targeted therapy
4) Association with massive splenomegaly

7. Which of the following is not included in laboratory criteria of diagnosis of Antiphospholipid Syndrome?
1) Anti-factor Xa activity
2) Lupus anticoagulant
3) Anti-cardiolipin antibodies
4) Anti β-2 GP-1 antibodies

8. Which of the following is not an associated risk factor of Coronary Artery Disease:
1) Sedentary life style
2) Raised Hs-CRP
3) High homocysteine levels
4) High serum HDL level

9. Which of the enzymes is not involved in free radical scavenging systems
1) Phospholipases
2) Superoxide dismutases
3) Catalase
4) Glutathione Peroxidase

10. Pro-apoptotic proteins are :-
1) bcl 2-bcl xL
2) bcl 2 – Mcl-1
3) Bax and Bak
4) Ced 9

11. Which stain is used in frozen section of liver tissue for demonstration of fat
1) Mucicarmine
2) Periodic Acid Schiff
3) Alcian blue
4) Oil Red O

12. The pigment deposited in collagen of connective tissue in ochronosis is
1) Melanin
2) Hemosiderin
3) Homogentisic acid
4) Lipofuscin

13. Which cytokine regulates the expression of Selectins on endothelium and leucocytes
1) Interleukin 6
2) Tumour Necrosis Factor and Interleukin
3) Chemokines
4) Interferon gamma

14. Which inherited disease is related with defects in phagolysosome function
1) leukocyte adhesion deficiency
2) Chronic granulomatous disease
3) Chediak Higashi Syndrome
4) MPO deficiency

15. Which one of the following statements is NOT correct.
1) Familial amyloidotic neuropathy is associated with increase in Transthyretin
2) Primary amyloidosis is associated with immunoglobulin Light chains
3) Hemodialysis amyloidosis is associated with Transthyretin
4) Familial Mediterranean fever is associated with increase in Amyloid Associated protein

16. Which of the complement components act as a chemoattractant
1) C 4 b
2) C 4 a
3) C 3 b
4) C 5 a

17. Which one is NOT an Acute phase protein
1) Fibrinogen
2) Transferrin
3) C – reactive protein
4) Serum Amyloid A protein

18. Which one of the collagens is NOT a fibrillar collagen
1) Type I
2) Type II
3) Type IV
4) Type III

19. Which of the following cell adhesion proteins provides connection between cells and extracellular matrix
1) Integrins
2) Selectins
3) Cadherins
4) Immunoglobulin cell adhesion molecule

20. Which one of the following growth factor receptor is NOT associated with intrinsic tyrosine kinase activity
1) EGF
2) G-Protein coupled receptor
3) TGF-α
4) PDGF

21. Ki-67 nuclear protein is NOT expressed by cells in which phase of cell cycle
1) G1 Phase
2) G0 Phase
3) M Phase
4) S Phase

22. Intraepidermal bullae are not associated with
1) Pemphigus Vulgaris
2) Hailey Hailey disease
3) Bullous Pemphigoid
4) Spongiotic dermatitis

23. In which of the skin lesion, grains and corps ronds are found
1) Darier disease
2) Acanthosis Nigricans
3) Seborrhoeic dermatitis
4) Psoriasis

24. Which of the following immunohistochemistry markers is specific for basal cell carcinoma of the skin
1) EMA
2) CEA
3) Ber-EP4
4) CD34

25. Which one of the immunohistochemistry markers is NOT a positive marker for Mesothelioma of the pleura
1) Calretinin
2) WT-1
3) Cytokeratin 5/6
4) CEA

26. Which one is not associated with Kartagener’s syndrome
1) Emphysema
2) Bronchiectasis
3) Complete situs inversus
4) Infertility

27. Which one of the following pairs is NOT wrongly matched
1) Anthracosis – Coal dust
2) Silicosis – Quartz
3) Pleural plaques – Asbestos
4) Siderosis – beryllium

28. Which of the following is NOT correctly matched.
1) All transretinoic acid-AML-M3, t(15;17)
2) trastuzumab – Her-2/neu +ve breast cancer
3) Imatinib – CML t(9;22)
4) Gefitinib – NSCLC Alk Positive lung cancer

29. Pendred Syndrome is characterised by following EXCEPT
1) Hypothyroidism
2) Germline mutation in TTF-2
3) sensorineural deafness
4) mutation in SLC 26A4 gene

30. Medullary carcinoma thyroid is characterised by all EXCEPT
1) It arises from C-cells
2) Amyloid deposition
3) Thyroglobulin positive
4) Calcitonin positivity

31. Which of the following is NOT a specific Immunomarker for Gastrointestinal stromal tumour(GIST).
1) Desmin
2) CD34
3) CD117
4) DOG-1

32. Which one of the Intestinal polyposis Syndromes is associated with an increased risk of malignancy of the colon
1) Cowden Syndrome
2) Peutz – Jeghers Syndrome
3) Juvenile polyposis
4) Familial adenomatous polyposis

33. Familial adenomatous polyposis is associated with mutation of which gene.
1) MSH2/MLH1
2) APC
3) P53
4) K-ras

34. Which one is not associated with unconjugated hyperbilirubinemia
1) Hemolytic anaemia
2) Crigler Najjar Syndrome
3) Dubin- Johnson Syndrome
4) Gilbert Syndrome

35. Which of the serological markers in Hepatitis B is indicative of highly infectious state.
1) HBeAg
2) Anti HBe antibody
3) HBsAg
4) Anti HBc antibody

36. Which immunologic marker is used to differentiate liver cell Adenoma from hepatocellular Carcinoma.
1) EMA
2) Pan-Cytokeratin
3) Glypican 3
4) MOC 31

37. Which of the following is NOT included in Metabolic Syndrome
1) Obesity
2) Microalbuminaemia
3) Hypertension
4) Increase high density Lipoproteins

38. An intact endothelium elaborates all antithrombotic factors EXCEPT.
1) Thrombomodulin
2) Heparin like molecule
3) Thromboplastin
4) Tissue Factor pathway Inhibitor

39. What is the classic pattern of Karyotype in Klinefelter Syndrome.
1) 47XXY
2) 45XO
3) 48XXXY
4) 47XXX

40. Following are the causes of Left heart failure EXCEPT.
1) Ischemic heart disease
2) Hypertension
3) Cor pulmonale
4) Aortic Valvular disease

41. Accelerated phase in chronic Myelogenous Leukaemia is characterised by following EXCEPT.
1) Increase blast cells >= 20%
2) Peripheral blood basophilia >= 20%
3) Duplication of Ph chromosome
4) Progressive Splenomegaly

42. Which of the following tests is used for identification of nature of M-protein in Multiple Myeloma.
1) Urine electrophoresis
2) Single radial Immunodiffusion
3) Immunofixation
4) Serum Protein electrophoresis

43. According to WHO criteria for diagnosis of plasma cell myeloma, which statement is correct for plasma cells in bone marrow.
1) less than 10%
2) 10% or more
3) more than 20%
4) more than 15%

44. Granuloma in the lung are not seen in –
1) Berylliosis
2) Asbestosis
3) Sarcoidosis
4) Tuberculosis

45. Viral pneumonias are characterised by
1) Alveolar Exudates of neutrophils, fibrin
2) Interstitial infiltrates
3) Bronchiolitis mainly
4) No inflammatory cell reaction in lung parenchyma

46. Main common lung cancer in non smokers
1) Adenocarcinoma
2) Squamous cell carcinoma
3) Small cell carcinoma
4) Large cell carcinoma

47. Which chronic lung disease does not result in Cor pulmonale
1) Chronic bronchitis and emphysema
2) Anthracosis
3) Bronchial Asthma
4) Extensive interstitial pulmonary fibrosis

48. NESTROF test is used for screening of which disease in India
1) Malaria
2) Hepatitis
3) Sickle cell Anaemia
4) Thalassemia

49. Which of the following is an example of allergic purpura.
1) Ehler Danlos Syndrome
2) Henoch-Schonlein purpura
3) Senile purpura
4) Marfan’s Syndrome

50. Heinz bodies are observed in peripheral blood in cases of
1) G6PD Deficiency
2) Pyruvate kinase deficiency
3) Lead Poisoning
4) Pyrimidine 5 nucleotidase deficiency